Html code will be here
Microarray
CytoScan and OncoScan arrays for DNA copy number analysis
A complete chromosomal microarray solution for identifying aneuploidies, microdeletions, microduplications, LOH/AOH, and other chromosomal aberrations across the genome
for research applications.
A complete chromosomal microarray solution for identifying aneuploidies, microdeletions, microduplications, LOH/AOH, and other chromosomal aberrations across the genome
for research applications.
Complete CMA solution
One complete platform for cytogenetic analysis
- CytoScan AIRSimplifies genomic variant pathogenicity research and reporting with ACMG classifications, phenotype matching, literature searches, and historical data.
- Flexible reportingSupports customization, reporting, evaluation, sign-off, and LIMS export for laboratory workflows.
- Evidence supportEvidence-based database development links evidence with observations and supports internal database expansion.
- >99% genotype accuracyCytoScan hybrid-SNP arrays include large numbers of SNP and non-polymorphic probes to boost confidence in breakpoint determination and independently confirm copy number events throughout the genome.
Boost efficiency and productivity with arrays, reagents, instrumentation, software, and automated interpretation and reporting.
What CMA can detect
A genome-wide view of chromosomal changes in one workflow
-
Copy number changesGains, losses, microdeletions, microduplications and aneuploidies across the genome. -
LOH / AOH / cnLOHDetect loss of heterozygosity, absence of heterozygosity, and copy-neutral loss of heterozygosity. -
UPD and relatednessSupport research into UPD, regions identical by descent, zygosity, and consanguinity. -
MosaicismEvaluate mosaicism and sample heterogeneity in constitutional and oncology research applications.
Identify chromosomal aberrations quickly and easily with a complete platform that combines arrays, kitted reagents, instrumentation, ChAS software, and CytoScan AIR.
End-to-end workflow
From target preparation to data analysis
From target preparation to data analysis
The robust workflow is aligned with research laboratory requirements, with intuitive processes to streamline data analysis and reporting.
Target preparation
DNA amplification, fragmentation, and labeling.
Array processing
Automated array hybridization, washing, and staining.
Scanning
Fully integrated, automated array scanning.
Data analysis
Genome-wide view and analysis of chromosomal aberrations, SNP variants, and copy number determinations.
Research applications
For a wide range of cytogenetics research applications
It is the intended result of the complete process of presentation of textual material in order to communicate meaning.
It is the intended result of the complete process of presentation of textual material in order to communicate meaning.
Prenatal
Helps clinical researchers study congenital anomalies or genetic disorders in the fetus.
Postnatal
Helps clinical researchers study congenital anomalies, diseases, and developmental delays following birth.
POC
Helps researchers study chromosomal anomalies associated with miscarriage using fetal tissue after pregnancy loss.
Oncology
Helps clinical researchers study chromosomal aberrations associated with cancer.
Applied Biosystems microarrays support prenatal, postnatal, liquid tumor, solid tumor, fresh/frozen, and FFPE research application areas.
Table 1. CytoScan Suite specifications
| Specification | CytoScan HD Accel | CytoScan HD | CytoScan 750K | CytoScan Optima | CytoScan HT-CMA | CytoScan XON |
|---|---|---|---|---|---|---|
| Research applications | Fast turnaround with latest available content for prenatal, postnatal, and oncology research. | High genome-wide resolution of CNVs for applications in prenatal and postnatal research. | High genome-wide resolution to analyze copy number gains and losses for prenatal and postnatal research. | Low-cost genome-wide platform to detect aneuploidies and copy number losses and gains at lower resolution, optimized for constitutional cytogenetics research. | High-throughput, cost-effective, genome-wide copy number analysis for constitutional cytogenetics research and testing of relevant SNP variants. | Sensitive, high coverage, whole genome, single exon-level copy number analysis. Use as a stand-alone research tool or to confirm CNV findings with alternative technologies like next generation sequencing. |
| Sample types | Blood, buccal swabs, saliva, uncultured or cultured cells, chorionic villi, amniocytes, POC, and fresh, frozen, or FFPE tissue. | Blood, buccal swabs, saliva, uncultured or cultured cells, chorionic villi, amniocytes, and POC. | Blood, buccal swabs, saliva, uncultured or cultured cells, chorionic villi, amniocytes, and POC. | Blood, uncultured or cultured cells, chorionic villi, amniocytes, and POC. | Blood, buccal swabs, saliva, uncultured or cultured cells, chorionic villi, amniocytes, and POC. | Blood. Custom-built reference file enables other sources of DNA. |
| Size of aberration* (analytical claims) |
|
|
|
|
|
|
| Input DNA | 100 ng | 10-250 ng** | 10-250 ng** | 10-250 ng** | 100 ng | 100 ng |
| Probe structure |
|
|
|
|
|
|
| Protocol | 2 days | 3-4 days | 3-4 days | As little as 2.5 days | 4 days | 4 days |
* The size of the segment call depends on the average marker spacing in the
region. Best performance can be achieved in regions with higher marker
coverage. Mosaicism detection may depend on the size of the altered segment
and the type of aberration involved.
** 250 ng is optimal, but users have reported success using as little as 10 ng starting DNA.
** 250 ng is optimal, but users have reported success using as little as 10 ng starting DNA.
Oncology applications
For liquid and solid tumors research
- CytoScan HD Suite captures chromosomal abnormalities and genomic instability in hematologic malignancies research.
- OncoScan assays are designed to detect structural variants that may not be well characterized by short-read or targeted sequencing.
- Detect deletions, duplications, LOH, cnLOH, breakpoint determination, ploidy, mosaicism, and unbalanced translocations.